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Head Neck. 2018 Sep;40(9):1934-1946. doi: 10.1002/hed.25185. Epub 2018 Apr 17.

Locoregionally advanced oral cavity cancer: A propensity-score matched analysis on overall survival with emphasis on the impact of adjuvant radiotherapy.

Author information

1
Department of Radiation Oncology, Rush University Medical Center, Chicago, Illinois.
2
School of Dentistry, University of Michigan, Ann Arbor, Michigan.

Abstract

BACKGROUND:

The purpose of this study was to determine the impact of adjuvant radiotherapy (RT) in locoregionally advanced oral cavity cancer.

METHODS:

Data were extracted from the National Cancer Data Base, of which overall survival (OS) is the only outcome variable available. The chi-square test and Cox regression models were used.

RESULTS:

A total of 6654 patients were identified. The utilization of adjuvant RT has increased over time. A propensity matched cohort included 3946 patients, exactly one-half of whom received adjuvant RT. Independent predictors associated with receipt of adjuvant RT included age, Charlson/Deyo comorbidity score, extracapsular extension, surgical margins, and T and N classifications. On multivariable analysis, adjuvant RT remained an independent prognosticator for OS.

CONCLUSION:

Receipt of adjuvant RT is a prognostic factor associated with improved OS, its utilization has increased over time, and it should be considered for clinically suitable patients who have undergone resection for the disease.

KEYWORDS:

adjuvant radiotherapy; locoregionally advanced; oral cavity cancer; outcomes; prognostic factors

PMID:
29665118
DOI:
10.1002/hed.25185

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