Format

Send to

Choose Destination
Microbiol Res. 2018 May;210:59-64. doi: 10.1016/j.micres.2018.03.008. Epub 2018 Mar 19.

Inhibition of coxsackievirus B4 by Lactobacillus plantarum.

Author information

1
Dipartimento di Scienze degli Alimenti, Facoltà di Agraria, Università degli Studi di Foggia, 71122 Foggia, Italy.
2
Université de Lille, Faculté de Médecine, CHRU Lille, Laboratoire de Virologie/EA3610, F-59000 Lille, France.
3
Université de Lille-ICV-Institut Charles Viollette, EA7394, F-59000 Lille, France.
4
Dipartimento di Medicina Clinica e Sperimentale, Polo Biomedico E. Altomare, Università degli Studi di Foggia, 71122 Foggia, Italy.
5
Dipartimento di Scienze degli Alimenti, Facoltà di Agraria, Università degli Studi di Foggia, 71122 Foggia, Italy. Electronic address: giuseppe.spano@unifg.it.

Abstract

The enterovirus Coxsackievirus B4 (CV-B4) can infect different human tissues and provoke abnormal function or destruction of various organs and cells. Moreover, its infections have been linked to the onset of type 1 diabetes. Coxsackievirus B4 is classified as a "challenging virus", due to the intense yet vain efforts to find effective prevention and therapeutic agents, especially within biological compounds. Lactobacillus plantarum is a lactic acid bacterium that is endowed with probiotic properties, and holds great potential for applications in medical and food industry sectors. Several compounds produced by this microorganism have been associated with various benefits including antimicrobial activity. In this work, we investigated the possible antiviral abilities of two Lb. plantarum strains and their derivatives against CV-B4. The different assays carried out (e.g. pre-incubation, competition and post-infection, using HEp-2 cells as human cell model) suggest that the tested microorganisms and their derivatives have an in vitro inhibiting activity against CV-B4. This is the first report showing the anti-CVB4 activity of Lb. plantarum strains and their derivatives.

KEYWORDS:

Antiviral activity; Cell free supernatant; Enterovirus; HEp-2 cells; In vitro; Lactobacillus plantarum

PMID:
29625659
DOI:
10.1016/j.micres.2018.03.008
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center