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Nat Cell Biol. 2018 Apr;20(4):382-392. doi: 10.1038/s41556-018-0067-6. Epub 2018 Mar 28.

Deconstructing the pluripotency gene regulatory network.

Author information

1
King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia. mo.li@kaust.edu.sa.
2
Salk Institute for Biological Studies, La Jolla, CA, USA. belmonte@salk.edu.

Abstract

Pluripotent stem cells can be isolated from embryos or derived by reprogramming. Pluripotency is stabilized by an interconnected network of pluripotency genes that cooperatively regulate gene expression. Here we describe the molecular principles of pluripotency gene function and highlight post-transcriptional controls, particularly those induced by RNA-binding proteins and alternative splicing, as an important regulatory layer of pluripotency. We also discuss heterogeneity in pluripotency regulation, alternative pluripotency states and future directions of pluripotent stem cell research.

PMID:
29593328
PMCID:
PMC6620196
DOI:
10.1038/s41556-018-0067-6
[Indexed for MEDLINE]
Free PMC Article

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