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J Clin Transl Endocrinol. 2018 Feb 14;11:18-25. doi: 10.1016/j.jcte.2018.01.003. eCollection 2018 Mar.

Marked improvement of thyroid function and autoimmunity by Aloe barbadensis miller juice in patients with subclinical hypothyroidism.

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Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Italy.
Department of Clinical and Experimental Medicine, University of Messina, University Hospital Policlinico G. Martino Padiglione B, Via Consolare Valeria, 98100 Messina, Italy.
Department of Clinical and Experimental Medicine, University of Messina, Italy.
Master Program on Childhood, Adolescent and Women's Endocrine Health, University of Messina, Italy.
Interdept. Program of Molecular & Clinical Endocrinology and Women's Endocrine Health, University Hospital Policlinico G. Martino, Padiglione H, Messina, Italy.


Some natural compounds decrease serum levels of thyroid autoantibodies, but results are inconsistent and thyroid function has been evaluated infrequently; moreover, the effects of Aloe on thyroid autoimmunity and function have been examined in very few studies. This study stems from the observation of one co-author, who has Hashimoto's thyroiditis (HT)-related subclinical hypothyroidism (SCH). Upon checking her biochemical thyroid panel when taking daily Aloe barbardensis Miller juice (ABMJ) for thyroid-unrelated reasons, she noticed a decrease in serum thyroperoxidase autoantibodies (TPOAb) and thyrotropin (TSH) and an increase in serum free thyroxine (FT4). Based on this observation, we enrolled 30 consecutive HT women with levothyroxine-untreated SCH and high TPOAb levels. All of them took ABMJ (50 ml daily) for nine months and were tested for serum TSH, FT4, free triiodothyronine (FT3) and TPOAb. Measurements were performed at baseline and at months 3 and 9. TSH, FT4 and TPOAb improved significantly already at month 3 and further (-61%, +23% and -56%) at month 9. However, FT3 decreased significantly at month 3 (-16%) with no further decrease at month 9, so that the FT4:FT3 ratio increased significantly (+33% and + 49%). At baseline, 100% of women had TSH > 4.0 mU/L and TPOAb > 400 U/ml, but frequencies fell to 0% and 37%, respectively, at month 9. In contrast, a control group (namely, 15 untreated SCH women of comparable age and baseline levels of TSH, FT4, FT3 and TPOAb) had no significant changes in any index. We conclude that the daily intake of 100 ml ABMJ for 9 months in women with HT-related SCH decreases the burden of thyroid autoimmune inflammation. In addition, ABMJ rescues thyrocyte function, with decreased need for conversion of the prohormone T4 into the more active T3 through ABMJ-induced inhibition of T4 deiodination.


Aloe vera; Subclinical hypothyroidism; Thyroid autoimmunity; Thyroid function

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