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Oral Dis. 2018 Mar;24(1-2):261-276. doi: 10.1111/odi.12796.

Learning from clinical phenotypes: Low-dose biophotonics therapies in oral diseases.

Author information

1
Oral Biology, School of Dental Medicine, University at Buffalo, Buffalo, NY, USA.
2
Energetic and Nuclear Research Institute, Radiation Technology Center, São Paulo, Brazil.
3
Biomedical Engineering and Bioengineering, Universidade Brasil, São Paulo, Brazil.
4
Restorative and Implant Dentistry, School of Dental Medicine, University at Buffalo, Buffalo, NY, USA.
5
Oral and Maxillofacial Surgery, School of Dental Medicine, University at Buffalo, Buffalo, NY, USA.

Abstract

This narrative review on the use of biophotonics therapies for management of oral diseases is written as a tribute to Prof. Crispian Scully. His seminal contributions to the field are highlighted by the detailed, comprehensive description of clinical presentations of oral diseases. This has enabled a more thorough, fundamental understanding of many of these pathologies by research from his group as well as inspired mechanistic investigations in many groups globally. In the same vein, a major emphasis of this narrative review is to focus on the evidence from human case reports rather than in vitro or in vivo animal studies that showcases the growing and broad impact of biophotonics therapies. The similarities and differences between two distinct forms of low-dose biophotonics treatments namely photodynamic therapy and photobiomodulation therapy are discussed. As evident in this review, a majority of these reports provide promising evidence for their clinical efficacy. However, a lack of adequate technical details, precise biological rationale, and limited outcome measures limits the current utility of these treatments. Future investigations should attempt to address these shortcomings and develop better designed, rigorous, controlled studies to fully harness the tremendous potential of low-dose biophotonics therapies.

KEYWORDS:

anti-microbial; inflammation; low level light/laser therapy; oral diseases; photobiomodulation therapy; photodynamic therapy; wound healing

PMID:
29480614
DOI:
10.1111/odi.12796
[Indexed for MEDLINE]

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