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Science. 2018 Mar 16;359(6381). pii: eaao0318. doi: 10.1126/science.aao0318. Epub 2018 Feb 8.

Diurnal transcriptome atlas of a primate across major neural and peripheral tissues.

Author information

1
Regulatory Biology Laboratory, Salk Institute for Biological Studies, 10010, North Torrey Pines Road, La Jolla, CA 92037, USA.
2
Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
3
Institute of Primate Research (IPR), National Museums of Kenya, Nairobi, Kenya.
4
Université Lyon, Universite Claude Bernard Lyon 1, Inserm, Stem Cell and Brain Research Institute U1208, 69500 Bron, France.
5
Université Lyon, Universite Claude Bernard Lyon 1, Inserm, Stem Cell and Brain Research Institute U1208, 69500 Bron, France. howard.cooper@inserm.fr satchin@salk.edu.
6
Regulatory Biology Laboratory, Salk Institute for Biological Studies, 10010, North Torrey Pines Road, La Jolla, CA 92037, USA. howard.cooper@inserm.fr satchin@salk.edu.

Abstract

Diurnal gene expression patterns underlie time-of-the-day-specific functional specialization of tissues. However, available circadian gene expression atlases of a few organs are largely from nocturnal vertebrates. We report the diurnal transcriptome of 64 tissues, including 22 brain regions, sampled every 2 hours over 24 hours, from the primate Papio anubis (baboon). Genomic transcription was highly rhythmic, with up to 81.7% of protein-coding genes showing daily rhythms in expression. In addition to tissue-specific gene expression, the rhythmic transcriptome imparts another layer of functional specialization. Most ubiquitously expressed genes that participate in essential cellular functions exhibit rhythmic expression in a tissue-specific manner. The peak phases of rhythmic gene expression clustered around dawn and dusk, with a "quiescent period" during early night. Our findings also unveil a different temporal organization of central and peripheral tissues between diurnal and nocturnal animals.

Comment in

PMID:
29439024
PMCID:
PMC5924732
[Available on 2019-03-16]
DOI:
10.1126/science.aao0318
[Indexed for MEDLINE]

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