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Eye (Lond). 2018 Jun;32(6):1079-1086. doi: 10.1038/s41433-018-0029-z. Epub 2018 Feb 12.

Comparison of photodynamic therapy and navigated microsecond laser for chronic central serous chorioretinopathy.

Author information

1
Comprehensive Community Based Rehabilitation in Tanzania (CCBRT), Dar es Salaam, Tanzania.
2
Giridhar Eye Institute, Ponneth Temple Road, Kadavanthra, Cochin, 682020, Kerala, India.
3
University of Nairobi, Nairobi, Kenya.
4
Smt. Kanuri Santhamma Centre for Vitreo Retinal Diseases, L V Prasad Eye Institute, Hyderabad, Andhra Pradesh, India.
5
Smt. Kanuri Santhamma Centre for Vitreo Retinal Diseases, L V Prasad Eye Institute, Hyderabad, Andhra Pradesh, India. jay.chhablani@gmail.com.

Abstract

OBJECTIVES:

To compare the visual and anatomical outcomes after photodynamic therapy (PDT) and navigated microsecond laser (nMSL) for chronic central serous chorioretinopathy (CSCR).

METHODS:

This retrospective study included eyes with chronic CSCR who underwent either PDT or nMSL with a minimum of 6 months' follow-up. Eyes with a history of treatment with any other modalities in the past or during 6 months post PDT or microsecond laser follow-up were excluded. Primary outcome measures included change in best-corrected visual acuity (BCVA) and central macular thickness (CMT). Secondary outcome measures included changes in subretinal fluid, hyper-reflective foci, cystic spaces, subfoveal choroidal thickness, and outer retinal structure integrity.

RESULTS:

Forty-five eyes of 39 subjects (PDT group-23 eyes, nMSL group-22 eyes) with chronic CSCR were analyzed. At 6 months' follow-up, the nMSL group had significantly higher improvement in visual acuity compared to the PDT group (0.12 ± 0.24 vs -0.02 ± 0.20 (p = 0.039)). Reduction in central macular thickness was significantly higher in nMSL group compared to the PDT (85.5 ± 93.26 vs 24.47 ± 73.18 microns (p = 0.02)). Thirteen (59%) eyes in nMSL group had complete resolution of the SRF at 6 months compared to 5 (21.7%) eyes in PDT group. There was no significant difference in rest of the anatomical features between the groups.

CONCLUSIONS:

nMSL seems to be superior over PDT in improving visual and anatomical outcomes at 6 months and can be considered as a cheap alternative to PDT in treatment of CSCR.

PMID:
29429986
PMCID:
PMC5997803
[Available on 2019-06-01]
DOI:
10.1038/s41433-018-0029-z
[Indexed for MEDLINE]

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