Format

Send to

Choose Destination
Eur J Neurosci. 2019 Mar;49(6):784-793. doi: 10.1111/ejn.13858. Epub 2018 Feb 28.

Diverse actions of the modulatory peptide neurotensin on central synaptic transmission.

Author information

1
Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104-5005, USA.

Abstract

Neurotensin (NT) is a 13 amino acid neuropeptide that is expressed throughout the central nervous system and is implicated in the etiology of multiple diseases and disorders. Many primary investigations of NT-induced modulation of neuronal excitability at the level of the synapse have been conducted, but they have not been summarized in review form in nearly 30 years. Therefore, the goal of this review is to discuss the many actions of NT on neuronal excitability across brain regions as well as NT circuit architecture. In the basal ganglia as well as other brain nuclei, NT can act through diverse intracellular signaling cascades to enhance or depress neuronal activity by modulating activity of ion channels, ionotropic and metabotropic neurotransmitter receptors, and presynaptic release of neurotransmitters. Further, NT can produce indirect effects by evoking endocannabinoid release, and recently has itself been identified as a putative retrograde messenger. In the basal ganglia, the diverse actions and circuit architecture of NT signaling allow for input-specific control of reward-related behaviors.

KEYWORDS:

VTA ; endocannabinoids; methamphetamine; neuropeptide; substantia nigra

PMID:
29405480
PMCID:
PMC6078827
[Available on 2020-03-01]
DOI:
10.1111/ejn.13858

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center