A case report of spontaneous staphylococcal meningitis in a cynomolgus monkey

Zhi Lin; Lu Zhang; Di Zhang; Guitao Huo; Xiaobing Zhou; Yan-Wei Yang; Yan Huo; Bo Li; Xing-Chao Geng

doi:10.1111/jmp.12330

A case report of spontaneous staphylococcal meningitis in a cynomolgus monkey

J Med Primatol. 2018 Apr;47(2):132-135. doi: 10.1111/jmp.12330. Epub 2018 Feb 5.

Authors

Zhi Lin¹, Lu Zhang², Di Zhang¹, Guitao Huo¹, Xiaobing Zhou¹, Yan-Wei Yang¹, Yan Huo¹, Bo Li¹, Xing-Chao Geng¹

Affiliations

¹ National Institute for Food and Drug Control, National Center for Safety Evaluation of Drugs, Beijing Key Lab for Pre-clinical Safety Evaluation of Drugs, Beijing, China.
² Key Laboratory of Digital Earth Science, Institute of Remote Sensing and Digital Earth, Chinese Academy of Sciences, Beijing, China.

PMID: 29399828
DOI: 10.1111/jmp.12330

Abstract

This report describes a suppurative meningitis in a young cynomolgus. The animal had neutrophil aggregation in the subarachnoid space and hemorrhage in bilateral adrenal glands. Staphylococcus was identified by FISH in brain. To our knowledge, this is the first case of staphylococcal meningitis with Waterhouse-Friderichsen syndrome in a cynomolgus monkey.

Keywords: Waterhouse-Friderichsen syndrome; bacterial diseases; nonhuman primates.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Brain / microbiology
Diagnosis, Differential
Macaca fascicularis*
Male
Monkey Diseases / diagnosis*
Monkey Diseases / pathology
Staphylococcal Infections / diagnosis
Staphylococcal Infections / pathology
Staphylococcal Infections / veterinary*
Staphylococcus aureus / isolation & purification*
Waterhouse-Friderichsen Syndrome / diagnosis
Waterhouse-Friderichsen Syndrome / pathology
Waterhouse-Friderichsen Syndrome / veterinary*