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J Turk Ger Gynecol Assoc. 2018 Aug 6;19(3):128-131. doi: 10.4274/jtgga.2018.0002. Epub 2018 Feb 2.

Association between fok1 polymorphism of vitamin D receptor gene with uterine leiomyoma in Turkish populations

Author information

Department of Molecular Medicine, Yeditepe University, Institute of Health Sciences, İstanbul, Turkey
Departments of Obstetrics and Gynecology, Yeditepe University School of Medicine, İstanbul, Turkey
Department of Medical Biology, Yeditepe University School of Medicine, İstanbul, Turkey



The aim of this research was to determine the association between the fok1 polymorphism and uterine leiomyomas.

Material and Methods:

For genotyping the fok1 polymorphism of the vitamin D receptor, real-time polymerase chain reaction was performed on blood samples of uterine leiomyoma (n=27) and control (n=33) groups. For statistical analyses, SPSS v.23 software (SPSS Inc., Chicago, IL, USA) was used.


A statistically significant difference was observed for the frequency of the CC genotype between the uterine leiomyoma and control groups, and the frequencies of the T allele in the uterine leiomyoma groups were significantly higher than in the control group.


The presence of the fok1 CC genotype may be a risk-reducing factor and the T allele may be a potential risk factor for developing uterine leiomyoma.


Vitamin D receptor; polymorphism; fok1; uterine leiomyoma

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