Format

Send to

Choose Destination
J Turk Ger Gynecol Assoc. 2018 Aug 6;19(3):128-131. doi: 10.4274/jtgga.2018.0002. Epub 2018 Feb 2.

Association between fok1 polymorphism of vitamin D receptor gene with uterine leiomyoma in Turkish populations

Author information

1
Department of Molecular Medicine, Yeditepe University, Institute of Health Sciences, İstanbul, Turkey
2
Departments of Obstetrics and Gynecology, Yeditepe University School of Medicine, İstanbul, Turkey
3
Department of Medical Biology, Yeditepe University School of Medicine, İstanbul, Turkey

Abstract

Objective:

The aim of this research was to determine the association between the fok1 polymorphism and uterine leiomyomas.

Material and Methods:

For genotyping the fok1 polymorphism of the vitamin D receptor, real-time polymerase chain reaction was performed on blood samples of uterine leiomyoma (n=27) and control (n=33) groups. For statistical analyses, SPSS v.23 software (SPSS Inc., Chicago, IL, USA) was used.

Results:

A statistically significant difference was observed for the frequency of the CC genotype between the uterine leiomyoma and control groups, and the frequencies of the T allele in the uterine leiomyoma groups were significantly higher than in the control group.

CONCLUSION:

The presence of the fok1 CC genotype may be a risk-reducing factor and the T allele may be a potential risk factor for developing uterine leiomyoma.

KEYWORDS:

Vitamin D receptor; polymorphism; fok1; uterine leiomyoma

Supplemental Content

Full text links

Icon for Galenos Yayinevi Icon for PubMed Central
Loading ...
Support Center