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Hum Brain Mapp. 2018 May;39(5):2111-2120. doi: 10.1002/hbm.23990. Epub 2018 Feb 1.

Frequency-dependent tACS modulation of BOLD signal during rhythmic visual stimulation.

Chai Y1,2,3, Sheng J1,3, Bandettini PA1, Gao JH2,3,4,5.

Author information

1
Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
2
Center for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
3
Beijing City Key Lab for Medical Physics and Engineering, Institution of Heavy Ion Physics, School of Physics, Peking University, Beijing, China.
4
McGovern Institute for Brain Research, Peking University, Beijing, China.
5
Shenzhen Institute of Neuroscience, Shenzhen, China.

Abstract

Transcranial alternating current stimulation (tACS) has emerged as a promising tool for modulating cortical oscillations. In previous electroencephalogram (EEG) studies, tACS has been found to modulate brain oscillatory activity in a frequency-specific manner. However, the spatial distribution and hemodynamic response for this modulation remains poorly understood. Functional magnetic resonance imaging (fMRI) has the advantage of measuring neuronal activity in regions not only below the tACS electrodes but also across the whole brain with high spatial resolution. Here, we measured fMRI signal while applying tACS to modulate rhythmic visual activity. During fMRI acquisition, tACS at different frequencies (4, 8, 16, and 32 Hz) was applied along with visual flicker stimulation at 8 and 16 Hz. We analyzed the blood-oxygen-level-dependent (BOLD) signal difference between tACS-ON vs tACS-OFF, and different frequency combinations (e.g., 4 Hz tACS, 8 Hz flicker vs 8 Hz tACS, 8 Hz flicker). We observed significant tACS modulation effects on BOLD responses when the tACS frequency matched the visual flicker frequency or the second harmonic frequency. The main effects were predominantly seen in regions that were activated by the visual task and targeted by the tACS current distribution. These findings bridge different scientific domains of tACS research and demonstrate that fMRI could localize the tACS effect on stimulus-induced brain rhythms, which could lead to a new approach for understanding the high-level cognitive process shaped by the ongoing oscillatory signal.

KEYWORDS:

brain oscillation; fMRI; tACS

PMID:
29389051
PMCID:
PMC6141005
DOI:
10.1002/hbm.23990
[Indexed for MEDLINE]
Free PMC Article

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