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Neurol Ther. 2018 Jun;7(1):155-159. doi: 10.1007/s40120-018-0092-1. Epub 2018 Jan 30.

Treatment with Botulinum Toxin for Refractory Fever Caused by Severe Spasticity: A Case Series.

Author information

1
Neurology/Movement Disorders, Instituto Mexicano de Neurociencias, Hospital Angeles Lomas, Huixquilucan, Estado de México, Mexico. jacobolester@hotmail.com.
2
Anesthesiology, Hospital Angeles Lomas, Huixquilucan, Estado de México, Mexico.
3
Neurosurgery, Instituto Mexicano de Neurociencias, Hospital Angeles Lomas, Huixquilucan, Estado de México, Mexico.
4
Internal Medicine/Infectology, Hospital Angeles Lomas, Huixquilucan, Estado de México, Mexico.

Abstract

INTRODUCTION:

Brain and spinal cord injuries may cause very severe spasticity that occasionally may be associated with persistent fever.

CASE SERIES:

We present 14 patients with spasticity and persistent fever, treated with botulinum toxin type A. Their spasticity improved and the fever resolved within a period no greater than 48 h. In all cases, infectious and other non-infectious causes were ruled out.

CONCLUSIONS:

When sustained tonic muscular activity is associated with a significant increase in body temperature and is refractory to the usual drugs used for hyperpyrexia, type A botulinum toxin may be an effective treatment option to control both spasticity and fever.

KEYWORDS:

Botulinum toxin; Fever; Spasticity

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