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Nutrients. 2018 Jan 28;10(2). pii: E140. doi: 10.3390/nu10020140.

The Pharmabiotic Approach to Treat Hyperammonemia.

Author information

1
Department of Biomedical Sciences and Institute for Medical Science, Chonbuk National University Medical School, Jeonju, Chonbuk 54907, Korea. 2011liujing88@gmail.com.
2
Department of Biomedical Sciences and Institute for Medical Science, Chonbuk National University Medical School, Jeonju, Chonbuk 54907, Korea. enkhchmg2580@gmail.com.
3
Department of Biomedical Sciences and Institute for Medical Science, Chonbuk National University Medical School, Jeonju, Chonbuk 54907, Korea.
4
JINIS BDRD institute, JINIS Biopharmaceuticals Co., 913 Gwahak-Ro, Bongdong, Wanju, Chonbuk 55321, Korea. hyeonjin_kim@yahoo.com.
5
Department of Biomedical Sciences and Institute for Medical Science, Chonbuk National University Medical School, Jeonju, Chonbuk 54907, Korea. seonghong@chonbuk.ac.kr.

Abstract

Ammonia is constantly produced as a metabolic waste from amino acid catabolism in mammals. Ammonia, the toxic waste metabolite, is resolved in the liver where the urea cycle converts free ammonia to urea. Liver malfunctions cause hyperammonemia that leads to central nervous system (CNS) dysfunctions, such as brain edema, convulsions, and coma. The current treatments for hyperammonemia, such as antibiotics or lactulose, are designed to decrease the intestinal production of ammonia and/or its absorption into the body and are not effective, besides being often accompanied by side effects. In recent years, increasing evidence has shown that modifications of the gut microbiota could be used to treat hyperammonemia. Considering the role of the gut microbiota and the physiological characteristics of the intestine, the removal of ammonia from the intestine by modulating the gut microbiota would be an ideal approach to treat hyperammonemia. In this review, we discuss the significance of hyperammonemia and its related diseases and the efficacy of the current management methods for hyperammonemia to understand the mechanism of ammonia transport in the human body. The possibility to use the gut microbiota as pharmabiotics to treat hyperammonemia and its related diseases is also explored.

KEYWORDS:

ammonia; gut microbiota; hyperammonemia; pharmabiotics

PMID:
29382084
PMCID:
PMC5852716
DOI:
10.3390/nu10020140
[Indexed for MEDLINE]
Free PMC Article

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