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Exp Dermatol. 2018 Mar;27(3):289-292. doi: 10.1111/exd.13503.

Homeobox transcription factor DLX4 is not necessary for skin development and homeostasis.

Author information

1
Laboratory of Skin Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, USA.
2
Biodata Mining and Discovery Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, USA.

Abstract

Dlx4 is a member of a family of homeobox genes with homology to Drosophila distal-less (dll) gene. We show that Dlx4 expression pattern partially overlaps with its cis-linked gene Dlx3 during mouse development as well as in neonatal and adult skin. In mice, Dlx4 is expressed in the branchial arches, embryonic limbs, digits, nose, hair follicle and in the basal and suprabasal layers of mouse interfollicular epidermis. We show that inactivation of Dlx4 in mice did not result in any overtly gross pathology. Skin development, homeostasis and response to TPA treatment were similar in mice with loss of Dlx4 compared to wild-type counterparts.

KEYWORDS:

Dlx4 ; epidermis; homeobox transcription factor; skin homeostasis

PMID:
29380438
PMCID:
PMC5844850
DOI:
10.1111/exd.13503
[Indexed for MEDLINE]
Free PMC Article

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