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Brain Res. 2018 Mar 1;1682:36-43. doi: 10.1016/j.brainres.2017.12.040. Epub 2018 Jan 4.

Transcranial near-infrared photobiomodulation attenuates memory impairment and hippocampal oxidative stress in sleep-deprived mice.

Author information

1
Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran; Department of Medical Physics, Tabriz University of Medical Sciences, Tabriz, Iran.
2
Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran.
3
Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran; Higher Academic Education Institute of Rab-Rashid, Tabriz, Iran.
4
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
5
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, United States; Department of Dermatology, Harvard Medical School, Boston, MA 02115, United States; Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, United States.
6
Department of Medical Physics, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Medical Bioengineering, Tabriz University of Medical Sciences, Tabriz, Iran; School of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom.
7
Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: mahmoudij@tbzmed.ac.ir.

Abstract

Sleep deprivation (SD) causes oxidative stress in the hippocampus and subsequent memory impairment. In this study, the effect of near-infrared (NIR) photobiomodulation (PBM) on learning and memory impairment induced by acute SD was investigated. The mice were subjected to an acute SD protocol for 72 h. Simultaneously, NIR PBM using a laser at 810 nm was delivered (once a day for 3 days) transcranially to the head to affect the entire brain of mice. The Barnes maze and the What-Where-Which task were used to assess spatial and episodic-like memories. The hippocampal levels of antioxidant enzymes and oxidative stress biomarkers were evaluated. The results showed that NIR PBM prevented cognitive impairment induced by SD. Moreover, NIR PBM therapy enhanced the antioxidant status and increased mitochondrial activity in the hippocampus of SD mice. Our findings revealed that hippocampus-related mitochondrial damage and extensive oxidative stress contribute to the occurrence of memory impairment. In contrast, NIR PBM reduced hippocampal oxidative damage, supporting the ability of 810 nm laser light to improve the antioxidant defense system and maintain mitochondrial survival. This confirms that non-invasive transcranial NIR PBM therapy ameliorates hippocampal dysfunction, which is reflected in enhanced memory function.

KEYWORDS:

Antioxidant defense; Hippocampus; Memory; Mitochondria; Photobiomodulation; ROS

PMID:
29307593
PMCID:
PMC5801165
DOI:
10.1016/j.brainres.2017.12.040
[Indexed for MEDLINE]
Free PMC Article

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