Format

Send to

Choose Destination
Genome Med. 2018 Jan 4;10(1):1. doi: 10.1186/s13073-017-0512-3.

Modeling psychiatric disorders using patient stem cell-derived neurons: a way forward.

Author information

1
Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA.
2
Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA. gage@salk.edu.

Abstract

Our understanding of the neurobiology of psychiatric disorders remains limited, and biomarker-based clinical management is yet to be developed. Induced pluripotent stem cell (iPSC) technology has revolutionized our capacity to generate patient-derived neurons to model psychiatric disorders. Here, we highlight advantages and caveats of iPSC disease modeling and outline strategies for addressing current challenges.

PMID:
29301565
PMCID:
PMC5755287
DOI:
10.1186/s13073-017-0512-3
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center