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Mitochondrion. 2019 Jan;44:1-6. doi: 10.1016/j.mito.2017.12.004. Epub 2017 Dec 16.

Involvement of mitochondrial haplogroups in myocardial infarction and stroke: A case-control study in Castile and Leon (Spain) population.

Author information

1
Unitat d'Antropologia Biològica, Department BABVE, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Barcelona, Spain.
2
Dirección General de Salud Pública, Consejería de Sanidad, Junta de Castilla y León, 47007 Valladolid, Spain.
3
Unitat d'Antropologia Biològica, Department BABVE, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Barcelona, Spain. Electronic address: cristina.santos@uab.cat.
4
Unitat d'Antropologia Biològica, Department BABVE, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Barcelona, Spain. Electronic address: mariapilar.aluja@uab.cat.

Abstract

There are strong evidences that common mitochondrial DNA (mtDNA) haplogroups may influence the pathogenesis of cardiovascular diseases (CVDs). In this matched case-control study, we investigate the association between mtDNA haplogroups and two CVDs, myocardial infarction (MI) and stroke, and classical cardiovascular risk factors. Data obtained show that haplogroup H constitute a susceptibility risk factor for MI (p=0.001; OR=2.379, 95% CI [1.440-3.990]). Otherwise, our data also suggest a beneficial role of haplogroup J against hypertension (p=0.019; OR=0.348, 95% CI [0.144-0.840]). These results may provide some guidance for predicting the genetic risk of these diseases in different human populations through the differences in energy efficiency between haplogroups.

KEYWORDS:

Cardiovascular disease; Hypertension; Myocardial infarction; Spain; Stroke; mtDNA haplogroups

PMID:
29258787
DOI:
10.1016/j.mito.2017.12.004
[Indexed for MEDLINE]

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