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J Med Chem. 2018 Jan 11;61(1):81-83. doi: 10.1021/acs.jmedchem.7b01645. Epub 2017 Dec 19.

Mind Your Ears: A New Antidote to Aminoglycoside Toxicity?

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1
Stanford University , 801 Welch Road, Palo Alto, California 94305, United States.

Abstract

Aminoglycoside antibiotics are known toxins to cochlear hair cells, causing permanent hearing loss. Using the zebrafish lateral line system as a platform for drug screen and subsequent validation in the rat cochlea in vivo, Chowdhury et al. characterized a novel otoprotectant working against aminoglycoside-induced hearing loss.

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