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BMC Infect Dis. 2017 Dec 18;17(1):774. doi: 10.1186/s12879-017-2870-2.

Streptococcal toxic shock syndrome caused by the dissemination of an invasive emm3/ST15 strain of Streptococcus pyogenes.

Author information

1
Pathogen Genomics Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo, 162-8640, Japan.
2
Department of Pediatrics, Showa General Hospital, 8-1-1 Hanakoganei, Kodaira, Tokyo, 187-8510, Japan.
3
Department of Pediatrics, Showa General Hospital, 8-1-1 Hanakoganei, Kodaira, Tokyo, 187-8510, Japan. oba.k@showa-hp.jp.
4
Pathogen Genomics Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo, 162-8640, Japan. makokuro@niid.go.jp.

Abstract

BACKGROUND:

Streptococcus pyogenes (group A Streptococcus [GAS]) is a major human pathogen that causes a wide spectrum of clinical manifestations. Although invasive GAS (iGAS) infections are relatively uncommon, emm3/ST15 GAS is a highly virulent, invasive, and pathogenic strain. Global molecular epidemiology analysis has suggested that the frequency of emm3 GAS has been recently increasing.

CASE PRESENTATION:

A 14-year-old patient was diagnosed with streptococcal toxic shock syndrome and severe pneumonia, impaired renal function, and rhabdomyolysis. GAS was isolated from a culture of endotracheal aspirates and designated as KS030. Comparative genome analysis suggested that KS030 is classified as emm3 (emm-type) and ST15 (multilocus sequencing typing [MLST]), which is similar to iGAS isolates identified in the UK (2013) and Switzerland (2015).

CONCLUSIONS:

We conclude that the global dissemination of emm3/ST15 GAS strain has the potential to cause invasive disease.

KEYWORDS:

Invasive; ST15; Streptococcus pyogenes; Whole-genome sequencing; emm3

PMID:
29254479
PMCID:
PMC5735678
DOI:
10.1186/s12879-017-2870-2
[Indexed for MEDLINE]
Free PMC Article

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