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Psychiatry Res. 2018 Feb;260:360-365. doi: 10.1016/j.psychres.2017.12.005. Epub 2017 Dec 6.

Bench to bedside review: Possible role of vitamin D in autism spectrum disorder.

Author information

1
Department of Developmental and Behavioral Pediatrics, the First Hospital of Jilin University, Changchun, China.
2
Department of Psychiatry, University Medical Center Utrecht, Netherlands.
3
Neurological Research Center of First Hospital of Jilin University, Changchun, China; Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
4
Department of Developmental and Behavioral Pediatrics, the First Hospital of Jilin University, Changchun, China; Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt. Electronic address: ksaad8@yahoo.com.

Abstract

Autism spectrum disorder (ASD) is a group of dysfunctions in social interaction, communication, and behaviors. Studies have demonstrated that vitamin D deficiency during pregnancy and in individuals increased the risk of ASD. A genetic polymorphism study has pinpointed that genotype AA/A-allele of GC rs4588 in children is associated with ASD, which encodes the vitamin D binding protein. Translating the mentioned points into clinical practice, several clinical trials have demonstrated that vitamin D supplementation can improve the core symptoms in children with ASD. One paper also showed that possible prophylactic effect for the reoccurrence of ASD by vitamin D supplement during pregnancy and early childhood. Herein, this review aims to address the recent advances in this field and to clarify the possible role of vitamin D in ASD.

KEYWORDS:

Autism spectrum disorder; Prophylaxis; Treatment; Vitamin D

PMID:
29241119
DOI:
10.1016/j.psychres.2017.12.005
[Indexed for MEDLINE]

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