Send to

Choose Destination
Free Radic Biol Med. 2018 Feb 1;115:246-251. doi: 10.1016/j.freeradbiomed.2017.12.006. Epub 2017 Dec 9.

Cardiovascular disease risk factors and oxidative stress among premenopausal women.

Author information

Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA.
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA. Electronic address:


Oxidative stress is one hypothesized mechanism linking anthropometric, behavioral, and medical risk factors with cardiovascular disease (CVD). We evaluated cross-sectional associations between CVD risk factors and biomarkers of oxidative stress, and investigated these biomarkers as predictors of incident diabetes and hypertension among premenopausal women. F2-isoprostane (F2-IsoP) and metabolite (15-F2t-IsoP-M), reliable biomarkers of oxidative stress, were measured in urine samples collected at enrollment from 897 premenopausal women (ages 35-54) enrolled in the Sister Study cohort without a CVD history. Blood pressure, waist circumference, and body mass index (BMI) were measured at enrollment by trained study personnel. Diabetes and cigarette smoking were self-reported via enrollment questionnaires. Over a maximum follow-up of 11.5 years, participants self-reported incident diabetes and hypertension diagnoses on mailed questionnaires. In cross-sectional analyses, both F2-IsoP and 15-F2t-IsoP-M were positively associated with BMI, waist circumference, diastolic blood pressure, and current smoking. F2-IsoP was elevated among those with diabetes, and 15-F2t-IsoP-M increased with higher systolic blood pressure. Prospective analyses suggested an increased hypertension risk among those with elevated 15-F2t-IsoP-M (highest vs. lowest quartile: hazard ratio=2.34; 95% CI: 1.20-4.56). Our results suggest that urinary F2-IsoP and 15-F2t-IsoP-M are positively associated with adiposity measures, blood pressure, and cigarette smoking. Further investigation is warranted to evaluate 15-F2t-IsoP-M as a predictor of hypertension.


Body mass index; Cardiovascular disease; F(2)-isoprostanes; Hypertension; Oxidative stress

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center