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J Clin Res Pediatr Endocrinol. 2018 Jul 31;10(3):289-293. doi: 10.4274/jcrpe.5374. Epub 2017 Dec 8.

Peripheral Neuropathy as a Complication of Diabetic Ketoacidosis in a Child with Newly Diagnosed Diabetes Type 1: A Case Report

Author information

1
The Children’s Memorial Health Institute, Clinic of Endocrinology and Diabetology, Warsaw, Poland
2
Jan Kochanowski University, The Faculty of Medicine and Health Sciences, Kielce, Poland

Abstract

Neurological complications of diabetic ketoacidosis are considered to be a serious clinical problem. The most common complication is cerebral edema. However, these neurological complications also include less common entities such as ischemic or hemorrhagic stroke, cerebral venous and sinus thrombosis or peripheral neuropathy. We present a case of a 9-year old girl admitted to our intensive care unit with new onset type 1 diabetes, diabetic ketoacidosis, cerebral edema, multifocal vasogenic brain lesions and bilateral lower limb peripheral paresis. The patient developed polydipsia and polyuria one week before admission. The initial blood glucose level was 1136 mg/dL and severe acidosis was present (pH 7.1; BE-25.9). Computed tomography scan showed brain edema and a hypodense lesion in the left temporal region. Brain magnetic resonance imaging revealed more advanced multifocal brain lesions. Nerve conduction studies demonstrated damage of the motor neurons in both lower limbs with dysfunction in both peroneal nerves and the right tibial nerve. With treatment and physiotherapy, the patient’s health gradually improved. Acute neuropathy after ketoacidosis is a rare complication and its pathogenesis is not clear. Patients with diabetic ketoacidosis require careful monitoring of neurological function, even after normalization of their glycemic parameters.

KEYWORDS:

Polyneuropathy; ketoacidosis; diabetes mellitus type 1; children

PMID:
29217500
PMCID:
PMC6083477
DOI:
10.4274/jcrpe.5374
[Indexed for MEDLINE]
Free PMC Article

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