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Cell Tissue Res. 2018 Sep;373(3):693-709. doi: 10.1007/s00441-017-2735-4. Epub 2017 Nov 29.

Review: adult neurogenesis contributes to hippocampal plasticity.

Author information

1
Laboratory of Genetics - LOG-G, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA.
2
Laboratory of Genetics - LOG-G, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA. gage@salk.edu.

Abstract

Adult hippocampal neurogenesis is the process by which new functional neurons are added to the adult dentate gyrus of the hippocampus. Animal studies have shown that the degree of adult hippocampal neurogenesis is regulated by local environmental cues as well as neural network activities. Furthermore, accumulating evidence has suggested that adult hippocampal neurogenesis plays prominent roles in hippocampus-dependent brain functions. In this review, we summarize the mechanisms underlying the regulation of adult hippocampal neurogenesis at various developmental stages and propose how adult-born neurons contribute to structural and functional hippocampal plasticity.

KEYWORDS:

Adult hippocampal neurogenesis; Hippocampal plasticity; Learning; Memory; Pattern separation

PMID:
29185071
DOI:
10.1007/s00441-017-2735-4
[Indexed for MEDLINE]

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