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Brain Struct Funct. 2018 Mar;223(2):1017-1024. doi: 10.1007/s00429-017-1562-4. Epub 2017 Nov 16.

Connexin 30 is expressed in a subtype of mouse brain pericytes.

Mazaré N1,2,3, Gilbert A1,2,3, Boulay AC1,2,3, Rouach N1,2,3, Cohen-Salmon M4,5,6.

Author information

1
Collège de France, Center for Interdisciplinary Research in Biology (CIRB)/Centre National de La Recherche Scientifique CNRS, Unité Mixte de Recherche 7241/Institut National de la Santé et de la Recherche Médicale INSERM, U1050/Neuroglial Interactions in Cerebral Physiopathology, 75231, Paris Cedex 05, France.
2
University Pierre et Marie Curie, ED, N°158, 75005, Paris, France.
3
MEMOLIFE Laboratory of Excellence and Paris Science Lettre Research University, 75005, Paris, France.
4
Collège de France, Center for Interdisciplinary Research in Biology (CIRB)/Centre National de La Recherche Scientifique CNRS, Unité Mixte de Recherche 7241/Institut National de la Santé et de la Recherche Médicale INSERM, U1050/Neuroglial Interactions in Cerebral Physiopathology, 75231, Paris Cedex 05, France. martine.cohen-salmon@college-de-france.fr.
5
University Pierre et Marie Curie, ED, N°158, 75005, Paris, France. martine.cohen-salmon@college-de-france.fr.
6
MEMOLIFE Laboratory of Excellence and Paris Science Lettre Research University, 75005, Paris, France. martine.cohen-salmon@college-de-france.fr.

Abstract

Pericytes are mural cells of blood microvessels which play a crucial role at the neurovascular interface of the central nervous system. They are involved in the regulation of blood-brain barrier integrity, angiogenesis, clearance of toxic metabolites, capillary hemodynamic responses, and neuroinflammation, and they demonstrate stem cell activity. Morphological and molecular studies to characterize brain pericytes recently pointed out some heterogeneity in pericyte population. Nevertheless, a clear definition of pericyte subtypes is still lacking. Here, we demonstrate that a fraction of brain pericytes express Connexin 30 (Cx30), a gap junction protein, which, in the brain parenchyma, was thought to be exclusively found in astrocytes. Cx30 could thus be a candidate protein in the composition of the gap junction channels already described between endothelial cells and pericytes. It could also form hemichannels or acts in a channel-independent manner to regulate pericyte morphology, as already observed in astrocytes. Altogether, our results suggest that Cx30 defines a novel brain pericyte subtype.

KEYWORDS:

Brain vessel; Connexin 30; Gap junction; Neurovascular unit; Pericyte

PMID:
29143947
DOI:
10.1007/s00429-017-1562-4

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