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J Genomics. 2017 Oct 29;5:128-131. doi: 10.7150/jgen.22393. eCollection 2017.

Exploring Effects of Sex and Diet on Drosophila melanogaster Head Gene Expression.

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Section of Developmental Genomics, Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Department of Ecology, Genetics and Evolution, IEGEBA (CONICET-UBA), Faculty of Exact and Natural Sciences, University of Buenos Aires, Ciudad Universitaria, C1428EHA, Buenos Aires, Argentina.
National Laboratory for the Genomics of Biodiversity, CINVESTAV, Irapuato, Guanajuato, Mexico.
Division of Biological Sciences, University of California San Diego, La Jolla CA 92093, USA.


Gene expression depends on sex and environment. We stringently explored the contributions of these effects in Drosophila melanogaster by rearing three distinct wildtype genotypes on isocaloric diets either high in protein or sugar followed by expression profiling of heads from the sexes. By using different genotypes as replicates we developed robust sex- and diet-biased expression responses.


Adult head; Drosophila melanogaster.; High protein diet; High sugar diet

Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

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