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Nutrients. 2017 Oct 27;9(11). pii: E1176. doi: 10.3390/nu9111176.

The Role of Mammalian Target of Rapamycin (mTOR) in Insulin Signaling.

Author information

1
Department of Molecular Medicine, School of Medicine, Gachon University, Incheon 21999, Korea. msyoon@gachon.ac.kr.

Abstract

The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that controls a wide spectrum of cellular processes, including cell growth, differentiation, and metabolism. mTOR forms two distinct multiprotein complexes known as mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2), which are characterized by the presence of raptor and rictor, respectively. mTOR controls insulin signaling by regulating several downstream components such as growth factor receptor-bound protein 10 (Grb10), insulin receptor substrate (IRS-1), F-box/WD repeat-containing protein 8 (Fbw8), and insulin like growth factor 1 receptor/insulin receptor (IGF-IR/IR). In addition, mTORC1 and mTORC2 regulate each other through a feedback loop to control cell growth. This review outlines the current understanding of mTOR regulation in insulin signaling in the context of whole body metabolism.

KEYWORDS:

insulin; mTOR complex1 (mTORC1); mTOR complex2 (mTORC2); mammalian target of rapamycin (mTOR); protein kinase B (PKB/Akt)

PMID:
29077002
PMCID:
PMC5707648
DOI:
10.3390/nu9111176
[Indexed for MEDLINE]
Free PMC Article

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