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Cancers (Basel). 2017 Oct 25;9(11). pii: E146. doi: 10.3390/cancers9110146.

Advances in Precision Medicine: Tailoring Individualized Therapies.

Author information

1
Centre for Cancer Research and Cell Biology, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7AE, UK. k.matchett@qub.ac.uk.
2
Department of Surgery, Trinity Translational Medicine Institute, Trinity College Dublin, College Green, Dublin 2, D08 W9RT, Ireland. LYNAMLEN@tcd.ie.
3
School of Medicine, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, D04 V1W8, Ireland. william.watson@ucd.ie.
4
Discipline of Surgery, School of Medicine, The Lambe Institute for Translational Research, National University of Ireland Galway, Galway H91 YR71, Ireland. james.brown@nuigalway.ie.

Abstract

The traditional bench-to-bedside pipeline involves using model systems and patient samples to provide insights into pathways deregulated in cancer. This discovery reveals new biomarkers and therapeutic targets, ultimately stratifying patients and informing cohort-based treatment options. Precision medicine (molecular profiling of individual tumors combined with established clinical-pathological parameters) reveals, in real-time, individual patient's diagnostic and prognostic risk profile, informing tailored and tumor-specific treatment plans. Here we discuss advances in precision medicine presented at the Irish Association for Cancer Research Annual Meeting, highlighting examples where personalized medicine approaches have led to precision discovery in individual tumors, informing customized treatment programs.

KEYWORDS:

Ireland Cancer Meeting; PDX; Xenografts; avatar, precision medicine; personalized; profiling

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