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Mol Cell. 2017 Oct 19;68(2):263-264. doi: 10.1016/j.molcel.2017.10.005.

Spt6 Gets in the Way of Polycomb to Promote ESC Pluripotency.

Author information

1
Institut de recherches cliniques de Montréal, 110 Avenue des Pins Ouest, Montréal, QC, Canada; Département de Médecine, Faculté de Médecine, Université de Montréal, 2900 Boulevard Édouard-Montpetit, Montréal, QC, Canada. Electronic address: francois.robert@ircm.qc.ca.

Abstract

Despite expressing high levels of Polycomb group proteins, embryonic stem cells (ESCs) are refractory to H3K27 trimethylation, notably at super-enhancers regulating key pluripotency genes. In this issue of Molecular Cell, Wang et al. (2017) report that the histone chaperone Spt6 prevents H3K27 trimethylation of key ESC super-enhancers.

PMID:
29053954
DOI:
10.1016/j.molcel.2017.10.005
[Indexed for MEDLINE]
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