Episode of Kasabach-Merritt phenomenon following Japanese encephalitis vaccination: Case report

Vaccine. 2017 Dec 4;35(48 Pt B):6594-6597. doi: 10.1016/j.vaccine.2017.08.011. Epub 2017 Oct 16.

Abstract

Kasabach-Merritt phenomenon (KMP) is a rare potentially life-threatening consumptive coagulopathy characterized by thrombocytopenia and hypofibrinogenemia occurring associated with the vascular tumors kaposiform hemangioendothelioma (KHE) and tufted angioma (TA). A 10-month old male infant, diagnosed with KHE on his left leg, underwent a rapid increase of the lesion and severe thrombocytopenia, one day after the first dose of inactivated Japanese encephalitis (JE) vaccination. The episode of KMP was treated successfully by steroid. KMP is a rare complication of vaccination that physicians should be aware of. Giving up the following vaccination to provide the recurrence of KMP is not recommended.

Keywords: Adverse events; Inactivated Japanese encephalitis vaccine; Kaposiform hemangioendothelioma (KHE); Kasabach-Merritt phenomenon.

Publication types

  • Case Reports

MeSH terms

  • Drug-Related Side Effects and Adverse Reactions
  • Encephalitis, Japanese / prevention & control
  • Humans
  • Infant
  • Japanese Encephalitis Vaccines / administration & dosage
  • Japanese Encephalitis Vaccines / adverse effects*
  • Kasabach-Merritt Syndrome / diagnosis
  • Kasabach-Merritt Syndrome / drug therapy
  • Kasabach-Merritt Syndrome / etiology*
  • Male
  • Steroids / administration & dosage
  • Steroids / therapeutic use
  • Thrombocytopenia / etiology
  • Vaccination / adverse effects*

Substances

  • Japanese Encephalitis Vaccines
  • Steroids