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Curr Genet. 2018 Apr;64(2):389-391. doi: 10.1007/s00294-017-0763-y. Epub 2017 Oct 10.

Bidirectional terminators: an underestimated aspect of gene regulation.

Author information

1
Institut de recherches cliniques de Montréal (IRCM), 110 Avenue des Pins Ouest, Montréal, QC, H2W 1R7, Canada. francois.robert@ircm.qc.ca.
2
Département de Médecine, Faculté de Médecine, Université de Montréal, 2900 Boulevard Edouard-Montpetit, Montréal, QC, H3T 1J4, Canada. francois.robert@ircm.qc.ca.

Abstract

Recent experimental and computational work revealed that transcriptional terminators in Saccharomyces cerevisiae can terminate transcription coming from both directions. This mechanism helps budding yeast cope with the pervasive nature of transcription by limiting aberrant transcription from invading neighboring genes.

KEYWORDS:

Bidirectional terminators; Cryptic transcription; Hrp1; Pervasive transcription; Saccharomyces cerevisiae; Transcription

PMID:
29018946
DOI:
10.1007/s00294-017-0763-y
[Indexed for MEDLINE]

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