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J Am Soc Nephrol. 2018 Jan;29(1):24-34. doi: 10.1681/ASN.2017010004. Epub 2017 Oct 9.

Precision Transplant Medicine: Biomarkers to the Rescue.

Naesens M1,2, Anglicheau D3,4,5,6,7.

Author information

1
Department of Microbiology and Immunology, Laboratory of Nephrology, Katholieke Universiteit Leuven, University of Leuven, Leuven, Belgium.
2
Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium.
3
Necker-Enfants Malades Institute, French National Institutes of Health and Medical Research U1151, Paris, France; dany.anglicheau@aphp.fr.
4
Paris Descartes, Sorbonne Paris Cité University, Paris, France.
5
Réseau Thématique de Recherche et de Soins Centaure, Paris, France.
6
Labex Transplantex, Paris, France; and.
7
Department of Nephrology and Kidney Transplantation, Necker Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.

Abstract

The concept that individuals with the same disease and a similar clinical presentation may have very different outcomes and need very different therapies is not novel. With the development of many innovative tools derived from the omics technologies, transplant medicine is slowly entering the era of precision medicine. Biomarkers are the cornerstone of precision medicine, which aims to integrate biomarkers with traditional clinical information and tailor medical care to achieve the best outcome for an individual patient. Here, we discuss the basic concepts of precision medicine and biomarkers, with a specific focus on progress in renal transplantation. We delineate the different types of biomarkers and provide a general assessment of the current applications and shortcomings of previously proposed biomarkers. We also outline the potential of precision medicine in transplantation. Moving toward precision medicine in the field of transplantation will require transplant physicians to embrace the increased complexity and expanded decision algorithms and therapeutic options that are associated with improved disease nosology.

KEYWORDS:

acute rejection; chronic allograft failure; chronic graft deterioration; kidney transplantation; transplant outcomes

PMID:
28993504
PMCID:
PMC5748900
DOI:
10.1681/ASN.2017010004
[Indexed for MEDLINE]
Free PMC Article

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