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Cell Metab. 2017 Oct 3;26(4):585-587. doi: 10.1016/j.cmet.2017.09.011.

Dietary Carbohydrates Impair Healthspan and Promote Mortality.

Author information

1
Energy Metabolism Laboratory, Institute of Translational Medicine, Swiss Federal Institute of Technology (ETH) Zurich, Zurich-Schwerzenbach 8603, Switzerland; Life Sciences Zurich Graduate School, Molecular and Translational Biomedicine Program, Zurich 8055, Switzerland.
2
Institute for Diabetes and Obesity, Helmholtz Zentrum M√ľnchen, Garching 85748, Germany.
3
Energy Metabolism Laboratory, Institute of Translational Medicine, Swiss Federal Institute of Technology (ETH) Zurich, Zurich-Schwerzenbach 8603, Switzerland. Electronic address: michael-ristow@ethz.ch.

Abstract

The prospective cohort study, named PURE, found that in >135,000 participants from 18 countries, nutritive carbohydrates increase human mortality, whereas dietary fat reduces it, requesting a fundamental change of current nutritional guidelines. Experimental evidence from animal models provides synergizing mechanistic concepts as well as pharmacological options to mimic low-carb or ketogenic diets.

PMID:
28978421
DOI:
10.1016/j.cmet.2017.09.011
[Indexed for MEDLINE]
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