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Adv Healthc Mater. 2017 Oct;6(19). doi: 10.1002/adhm.201700718. Epub 2017 Sep 25.

An Advanced Multifunctional Hydrogel-Based Dressing for Wound Monitoring and Drug Delivery.

Author information

1
Center for Advanced Materials and Related Technologies (CAMTEC), University of Victoria, Victoria, BC, V8P 5C2, Canada.
2
Center for Biomedical Research, University of Victoria, Victoria, BC, V8P 5C2, Canada.
3
Laboratory for Innovations in Microengineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria, BC, V8P 5C2, Canada.
4
Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, V8P 5C2, Canada.
5
Division of Engineering Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
6
Division of Plastic Surgery, Department of Surgery, Faculty of Medicine, Vancouver, BC, V5Z 1M9, Canada.

Abstract

Wound management is a major global challenge and poses a significant financial burden to the healthcare system due to the rapid growth of chronic diseases such as diabetes, obesity, and aging population. The ability to detect pathogenic infections and release drug at the wound site is of the utmost importance to expedient patient care. Herein, this study presents an advanced multifunctional dressing (GelDerm) capable of colorimetric measurement of pH, an indicator of bacterial infection, and release of antibiotic agents at the wound site. This study demonstrates the ability of GelDerm to detect bacterial infections using in vitro and ex vivo tests with accuracies comparable to the commercially available systems. Wireless interfaces to digital image capture hardware such as smartphones serve as a means for quantitation and enable the patient to record the wound condition at home and relay the information to the healthcare personnel for following treatment strategies. Additionally, the dressing is integrated within commercially available patches and can be placed on the wound without chemical or physical irritation. This study demonstrates the ability of GelDerm to eradicate bacteria by the sustained release of antibiotics. The proposed technology holds great promise in managing chronic and acute injuries caused by trauma, surgery, or diabetes.

KEYWORDS:

drug-delivery; infections; sensing; wound dressings; wound management

PMID:
28944601
PMCID:
PMC5845857
DOI:
10.1002/adhm.201700718
[Indexed for MEDLINE]
Free PMC Article

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