Format

Send to

Choose Destination
Curr Opin Neurobiol. 2017 Dec;47:38-43. doi: 10.1016/j.conb.2017.08.017. Epub 2017 Sep 20.

The diverse actions of astrocytes during synaptic development.

Author information

1
Salk Institute for Biological Studies, Molecular Neuroscience Laboratory, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA; Neurosciences Graduate Program, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA.
2
Salk Institute for Biological Studies, Molecular Neuroscience Laboratory, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA. Electronic address: nallen@salk.edu.

Abstract

In the developing brain, cortical circuits are established through a complex process of synaptogenesis, maturation, and synaptic pruning. Astrocytes carry out diverse functions during each of these stages to facilitate the formation of complex networks. Recent work has begun to demonstrate that these heterogeneous roles during excitatory synaptic development are determined by the astrocyte population, brain region, and neuron type. This review will focus on current findings which highlight cell type specific mechanisms of excitatory synaptogenesis, as well as multiple mechanisms engaged by astrocytes to facilitate synaptic maturation and pruning.

PMID:
28938161
DOI:
10.1016/j.conb.2017.08.017
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center