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Trends Parasitol. 2017 Nov;33(11):831-832. doi: 10.1016/j.pt.2017.08.007. Epub 2017 Sep 8.

Malaria Parasites in a Hungry Host: Kinases and Host Caloric Restriction Brought Together.

Author information

1
Department of Microbiology, Infection & Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC3800, Australia.
2
Department of Microbiology, Infection & Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC3800, Australia. Electronic address: christian.doerig@monash.edu.

Abstract

A study recently published in Nature links reduced calorie nutritional intake of host mice with (i) reduced severity of cerebral malaria, (ii) decreased parasitemia, and (iii) activation of a nutrient-sensing pathway that regulates the parasite's proliferation rate. Here, we discuss these findings in the context of human malaria pathology and Plasmodium kinomics.

PMID:
28923378
DOI:
10.1016/j.pt.2017.08.007
[Indexed for MEDLINE]

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