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Neuron. 2017 Sep 13;95(6):1406-1419.e5. doi: 10.1016/j.neuron.2017.08.033.

Laminar Organization of Encoding and Memory Reactivation in the Parietal Cortex.

Author information

1
Department of Psychology, Program in Neuroscience, Florida State University, Tallahassee, FL 32306, USA. Electronic address: awilber@fsu.edu.
2
Canadian Centre for Behavioural Neuroscience, The University of Lethbridge, Lethbridge, AB T1K 3M4, Canada; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA. Electronic address: iskelin@uci.edu.
3
Department of Statistics, Program in Neuroscience, Florida State University, Tallahassee, FL 32306, USA.
4
Canadian Centre for Behavioural Neuroscience, The University of Lethbridge, Lethbridge, AB T1K 3M4, Canada; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA.

Abstract

Egocentric neural coding has been observed in parietal cortex (PC), but its topographical and laminar organization is not well characterized. We used multi-site recording to look for evidence of local clustering and laminar consistency of linear and angular velocity encoding in multi-neuronal spiking activity (MUA) and in the high-frequency (300-900 Hz) component of the local field potential (HF-LFP), believed to reflect local spiking activity. Rats were trained to run many trials on a large circular platform, either to LED-cued goal locations or as a spatial sequence from memory. Tuning to specific self-motion states was observed and exhibited distinct cortical depth-invariant coding properties. These patterns of collective local and laminar activation during behavior were reactivated in compressed form during post-experience sleep and temporally coupled to cortical delta waves and hippocampal sharp-wave ripples. Thus, PC neuron motion encoding is consistent across cortical laminae, and this consistency is maintained during memory reactivation.

KEYWORDS:

delta wave; high-frequency local field potential; hippocampus; memory reactivation; modular organization; movement decoding; multi-unit activity; parietal cortex; posterior parietal cortex; template matching

PMID:
28910623
PMCID:
PMC5679317
DOI:
10.1016/j.neuron.2017.08.033
[Indexed for MEDLINE]
Free PMC Article

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