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PLoS Negl Trop Dis. 2017 Sep 11;11(9):e0005888. doi: 10.1371/journal.pntd.0005888. eCollection 2017 Sep.

Naturally acquired antibody responses to more than 300 Plasmodium vivax proteins in three geographic regions.

Author information

1
Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
2
Department of Medical Biology, University of Melbourne, Melbourne, Australia.
3
Mahidol Vivax Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
4
MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom.
5
Division of Malaria Research, Proteo-Science Center, Ehime University, Matsuyama, Japan.
6
Vector Borne Diseases Unit, PNG Institute of Medical Research, Madang, Papua New Guinea.
7
ISGlobal, Barcelona Centre for International Health Research (CRESIB), Hospital Clinic-Universitat de Barcelona, Barcelona, Spain.
8
Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil.
9
Instituto de Pesquisas Leônidas e Maria Deane, Manaus, Amazonas, Brazil.
10
Malaria: Parasites & Hosts Unit, Department of Parasites & Insect Vectors, Institut Pasteur, Paris, France.

Abstract

Plasmodium vivax remains an important cause of malaria in South America and the Asia-Pacific. Naturally acquired antibody responses against multiple P. vivax proteins have been described in numerous countries, however, direct comparison of these responses has been difficult with different methodologies employed. We measured antibody responses against 307 P. vivax proteins at the time of P. vivax infection, and at 2-3 later time-points in three countries. We observed that seropositivity rates at the time of infection were highest in Thailand, followed by Brazil then PNG, reflecting the level of antigenic input. The majority of sero-reactive antigens in all sites induced short-lived antibody responses with estimated half-lives of less than 6 months, although there was a trend towards longer-lived responses in PNG children. Despite these differences, IgG seropositivity rates, magnitude and longevity were highly and significantly rank-correlated between the different regions, suggesting such features are reflective of the individual protein.

PMID:
28892517
PMCID:
PMC5614652
DOI:
10.1371/journal.pntd.0005888
[Indexed for MEDLINE]
Free PMC Article

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