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J Clin Immunol. 2017 Oct;37(7):727-731. doi: 10.1007/s10875-017-0437-z. Epub 2017 Aug 31.

Helicobacter bilis-Associated Suppurative Cholangitis in a Patient with X-Linked Agammaglobulinemia.

Author information

1
Université Paris Descartes - Sorbonne Paris Cité, Laboratoire de Microbiologie, Hôpital Necker-Enfants Malades, Assistance Publique - Hôpitaux de Paris, Paris, France. degand.n@chu-nice.fr.
2
CHU de Nice, Laboratoire de Bactériologie, 151 route St Antoine de Ginestière, BP 3079, 06202, Nice, Cedex 3, France. degand.n@chu-nice.fr.
3
Université Paris Descartes - Sorbonne Paris Cité, Service de Maladies infectieuses et Tropicales, Hôpital Necker-Enfants Malades, Centre d'Infectiologie Necker-Pasteur, Assistance Publique - Hôpitaux de Paris, Paris, France.
4
Université Paris Descartes - Sorbonne Paris Cité, Service d'Anatomopathologie, Hôpital Necker-Enfants Malades, Assistance Publique - Hôpitaux de Paris, Paris, France.
5
Université Paris Descartes - Sorbonne Paris Cité, Laboratoire de Microbiologie, Hôpital Necker-Enfants Malades, Assistance Publique - Hôpitaux de Paris, Paris, France.
6
Université Paris Descartes - Sorbonne Paris Cité, Service d'Hématologie, Hôpital Necker-Enfants Malades, Assistance Publique - Hôpitaux de Paris, Paris, France.
7
Université Paris Descartes - Sorbonne Paris Cité, Service d'Immuno-hématologie pédiatrique, Hôpital Necker-Enfants Malades, Assistance Publique - Hôpitaux de Paris, Paris, France.

Abstract

ᅟ: Helicobacter bilis is a commensal bacterium causing chronic hepatitis and colitis in mice. In humans, enterohepatic Helicobacter spp. are associated with chronic hepatobiliary diseases.

PURPOSE:

We aimed at understanding the microbial etiology in a patient with X-linked agammaglobulinemia presenting with suppurative cholangitis.

METHODS:

16S rDNA PCR directly performed on a liver biopsy retrieved DNA of H. bilis.

RESULTS:

Clinical outcome resulted in the normalization of clinical and biological parameters under antibiotic treatment by a combination of ceftriaxone, metronidazole, and doxycyclin followed by a 2-week treatment with moxifloxacin and a 2-month treatment with azithromycin.

CONCLUSION:

In conclusion, these data suggest a specific clinical and microbiological approach in patients with humoral deficiency in order to detect H. bilis hepatobiliary diseases.

KEYWORDS:

Bruton’s disease; Helicobacter bilis; agammaglobulinemia; cholangitis

PMID:
28856582
DOI:
10.1007/s10875-017-0437-z
[Indexed for MEDLINE]

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