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Methods Mol Biol. 2017;1627:81-89. doi: 10.1007/978-1-4939-7113-8_6.

Hypertrophic Scarring in the Rabbit Ear: A Practical Model for Studying Dermal Fibrosis.

Author information

1
Burn and Wound Healing Laboratory, Department of Surgery, Division of Plastic Surgery, University of British Columbia, Vancouver, BC, Canada.
2
Burn and Wound Healing Laboratory, Department of Surgery, Division of Plastic Surgery, University of British Columbia, Vancouver, BC, Canada. aghahary@mail.ubc.ca.

Abstract

Excessive fibrous tissue deposition after injury in the form of hypertrophic scar remains a major clinical challenge. The development of an animal model for such scarring has been extremely difficult because of a major difference between the healing process in laboratory animals and humans. Here, we describe the rabbit ear model for excessive dermal scarring which has some clinical and histological resemblance to human hypertrophic scar. Since its development, this model has been widely used to study the cellular and molecular biology of hypertrophic scarring and evaluate the efficacy of new therapeutic agents.

KEYWORDS:

Animal model; Dermal fibrosis; Hypertrophic scar; Rabbit ear

PMID:
28836196
DOI:
10.1007/978-1-4939-7113-8_6
[Indexed for MEDLINE]

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