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Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):E7641-E7649. doi: 10.1073/pnas.1705833114. Epub 2017 Aug 22.

Auxin minimum triggers the developmental switch from cell division to cell differentiation in the Arabidopsis root.

Author information

1
Dipartimento di Biologia e Biotecnologie, Laboratory of Functional Genomics and Proteomics of Model Systems, Università di Roma, Sapienza, 00185 Rome, Italy.
2
Unit of Chemical-Physics Fundamentals in Chemical Engineering, Department of Engineering, Università Campus Bio-Medico di Roma, 00128 Rome, Italy.
3
Computational and Systems Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, United Kingdom.
4
Department of Plant and Microbial Biology, North Carolina State University, Raleigh, NC 27695.
5
Department of Biology, Duke University, Durham, NC 27708.
6
Howard Hughes Medical Institute, Duke University, Durham, NC 27708.
7
Gregor Mendel Institute, Austrian Academy of Sciences, Vienna Biocenter, 1030 Vienna, Austria.
8
Umeå Plant Science Centre, Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences, SE-901 83 Umeå, Sweden.
9
Computational and Systems Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, United Kingdom; veronica.grieneisen@jic.ac.uk sabrina.sabatini@uniroma1.it.
10
Dipartimento di Biologia e Biotecnologie, Laboratory of Functional Genomics and Proteomics of Model Systems, Università di Roma, Sapienza, 00185 Rome, Italy; veronica.grieneisen@jic.ac.uk sabrina.sabatini@uniroma1.it.
11
Istituto Pasteur-Fondazione Cenci Bolognetti, 00100 Rome, Italy.

Abstract

In multicellular organisms, a stringent control of the transition between cell division and differentiation is crucial for correct tissue and organ development. In the Arabidopsis root, the boundary between dividing and differentiating cells is positioned by the antagonistic interaction of the hormones auxin and cytokinin. Cytokinin affects polar auxin transport, but how this impacts the positional information required to establish this tissue boundary, is still unknown. By combining computational modeling with molecular genetics, we show that boundary formation is dependent on cytokinin's control on auxin polar transport and degradation. The regulation of both processes shapes the auxin profile in a well-defined auxin minimum. This auxin minimum positions the boundary between dividing and differentiating cells, acting as a trigger for this developmental transition, thus controlling meristem size.

KEYWORDS:

cell differentiation; computational modeling; plant hormones; root meristem

PMID:
28831001
PMCID:
PMC5594665
DOI:
10.1073/pnas.1705833114
[Indexed for MEDLINE]
Free PMC Article

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