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Immunity. 2017 Aug 15;47(2):211-214. doi: 10.1016/j.immuni.2017.07.024.

A Rogue Foxp3 Mutant Undermines Treg Cell Function.

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1
Nomis Foundation Laboratories for Immunobiology and Microbial Pathogenesis, The Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: yzheng@salk.edu.

Abstract

Hayatsu et al. (2017) reveal that a FOXP3 mutant found in some patients afflicted with the autoimmune disease IPEX has broadened DNA-recognition specificity, directly repressing the expression of the gene encoding the transcription factor Batf. Their findings identify Batf as critical to tissue regulatory T cell function and suggest that polymorphisms that impact FOXP3 DNA-binding specificity may contribute susceptibility to autoimmune disease.

PMID:
28813651
DOI:
10.1016/j.immuni.2017.07.024
[Indexed for MEDLINE]
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