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Annu Rev Cell Dev Biol. 2017 Oct 6;33:203-217. doi: 10.1146/annurev-cellbio-100616-060654. Epub 2017 Aug 14.

Lessons from Interspecies Mammalian Chimeras.

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Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305; email:
Division of Stem Cell Therapy, Institute of Medical Science, University of Tokyo, Tokyo 108-0071, Japan.


As chimeras transform from beasts of Greek mythology into tools of contemporary bioscience, secrets of developmental biology and evolutionary divergence are being revealed. Recent advances in stem cell biology and interspecies chimerism have generated new models with extensive basic and translational applications, including generation of transplantable, patient-specific organs.


chimera; interspecies; organ niche; organogenesis; pluripotency

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