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Cell. 2017 Aug 10;170(4):599-600. doi: 10.1016/j.cell.2017.07.039.

Keeping the Rhythm while Changing the Lyrics: Circadian Biology in Aging.

Author information

1
Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Universidad Católica San Antonio de Murcia (UCAM), Guadalupe 30107 Murcia, Spain.
2
Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
3
Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address: belmonte@salk.edu.

Abstract

Aging and circadian rhythms have been linked for decades, but their molecular interplay has remained obscure. Sato et al. and Solanas et al. now reveal that, while core clock components remain nearly unaltered, aging is associated with tissue-specific rewiring, which can be prevented by calorie restriction.

PMID:
28802034
DOI:
10.1016/j.cell.2017.07.039
[Indexed for MEDLINE]
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