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Development. 2017 Jul 15;144(14):2544-2547. doi: 10.1242/dev.151183.

Interspecies chimeras for human stem cell research.

Author information

1
Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan.
2
Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan nakauchi@ims.u-tokyo.ac.jp.
3
Institute for Stem Cell Biology and Regenerative Medicine, Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.

Abstract

Interspecies chimeric assays are a valuable tool for investigating the potential of human stem and progenitor cells, as well as their differentiated progeny. This Spotlight article discusses the different factors that affect interspecies chimera generation, such as evolutionary distance, developmental timing, and apoptosis of the transplanted cells, and suggests some possible strategies to address them. A refined approach to generating interspecies chimeras could contribute not only to a better understanding of cellular potential, but also to understanding the nature of xenogeneic barriers and mechanisms of heterochronicity, to modeling human development, and to the creation of human transplantable organs.

KEYWORDS:

Chimeric assays; Heterochronicity; Human development; Interspecies chimera; Pluripotent stem cell

PMID:
28720651
DOI:
10.1242/dev.151183
[Indexed for MEDLINE]
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