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Nat Genet. 2017 Sep;49(9):1392-1397. doi: 10.1038/ng.3914. Epub 2017 Jul 17.

Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease.

Author information

1
Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2
Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.
3
Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.
4
Center for the Development of Therapeutics, Broad Institute, Cambridge, Massachusetts, USA.
5
Genomics plc, Oxford, UK.
6
Cancer Program, Broad Institute, Cambridge, Massachusetts, USA.

Abstract

UK Biobank is among the world's largest repositories for phenotypic and genotypic information in individuals of European ancestry. We performed a genome-wide association study in UK Biobank testing ∼9 million DNA sequence variants for association with coronary artery disease (4,831 cases and 115,455 controls) and carried out meta-analysis with previously published results. We identified 15 new loci, bringing the total number of loci associated with coronary artery disease to 95 at the time of analysis. Phenome-wide association scanning showed that CCDC92 likely affects coronary artery disease through insulin resistance pathways, whereas experimental analysis suggests that ARHGEF26 influences the transendothelial migration of leukocytes.

PMID:
28714974
PMCID:
PMC5577383
DOI:
10.1038/ng.3914
[Indexed for MEDLINE]
Free PMC Article

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