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J Am Chem Soc. 2017 Aug 9;139(31):10880-10886. doi: 10.1021/jacs.7b05916. Epub 2017 Jul 25.

Nanostructured Phthalocyanine Assemblies with Protein-Driven Switchable Photoactivities for Biophotonic Imaging and Therapy.

Author information

1
Department of Chemistry and Nano Science, Ewha Womans University , Seoul 120-750, Korea.
2
Department of Medicine, School of Medicine, Konkuk University , Seoul 143-701, Korea.
3
Department of Electrical Engineering and Creative IT Engineering, POSTECH , Pohang 37673, Korea.

Abstract

Switchable phototheranostic nanomaterials are of particular interest for specific biosensing, high-quality imaging, and targeted therapy in the field of precision nanomedicine. Here, we develop a "one-for-all" nanomaterial that self-assembles from flexible and versatile phthalocyanine building blocks. The nanostructured phthalocyanine assemblies (NanoPcTBs) display intrinsically unique photothermal and photoacoustic properties. Fluorescence and reactive oxygen species generation can be triggered depending on a targeted, protein-induced, partial disassembly mechanism, which creates opportunities for low-background fluorescence imaging and activatable photodynamic therapy. In vitro evaluations indicate that NanoPcTB has a high selectivity for biotin receptor-positive cancer cells (e.g., A549) compared to biotin receptor-negative cells (e.g., WI38-VA13) and permits a combined photodynamic and photothermal therapeutic effect. Following systemic administration, the NanoPcTBs accumulate in A549 tumors of xenograft-bearing mice, and laser irradiation clearly induces the inhibition of tumor growth.

PMID:
28708389
DOI:
10.1021/jacs.7b05916
[Indexed for MEDLINE]

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