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Am J Physiol Renal Physiol. 2017 Oct 1;313(4):F842-F846. doi: 10.1152/ajprenal.00313.2017. Epub 2017 Jul 12.

Dynamic regulation of lysine acetylation: the balance between acetyltransferase and deacetylase activities.

Author information

1
Division of Nephrology, Section of Cardio-Renal Physiology and Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama; and kellyhyndman@uabmc.edu.
2
Epithelial Systems Biology Laboratory, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.

Abstract

Reversible posttranslational modification of proteins is a critically important process in physiological regulation in all tissues, including the kidney. Lysine acetylation occurs in all organisms, including prokaryotes, and is regulated by a balance between the lysine acetyltransferases (adding an acetyl group to the ε-amino group of a lysine) and deacetylases (removing it). The kidney is an organ rich with acetylated lysines, which map to >2,000 unique histone and nonhistone proteins. However, the functional significance of these modifications remains to be discovered. Here, we have compiled gene lists of the acetyltransferases and deacetylases in the mammalian genomes and mapped their mRNA expression along the renal tubule. These lists will be useful for generating targeted approaches to test the physiological or pathophysiological significance of lysine acetylation changes in the kidney.

KEYWORDS:

acetyltransferase; deacetylase; histone; lysine acetylation; nephron

PMID:
28701313
PMCID:
PMC5668585
DOI:
10.1152/ajprenal.00313.2017
[Indexed for MEDLINE]
Free PMC Article

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