Format

Send to

Choose Destination
J Foot Ankle Surg. 2017 Jul - Aug;56(4):862-864. doi: 10.1053/j.jfas.2017.03.001.

Treatment of a Focal Articular Cartilage Defect of the Talus with Polymer-Based Autologous Chondrocyte Implantation: A 12-Year Follow-Up Period.

Author information

1
Professor, Orthopaedic Surgeon, Department of Orthopaedic Surgery, University Medical Center Rostock, Rostock, Germany.
2
Medical Student, Department of Orthopedic Surgery and Traumatology, Freiburg University Hospital, Freiburg, Germany. Electronic address: rhkalkreuth@gmail.com.
3
Professor, Orthopaedic Surgeon, Department of Orthopedic Surgery and Traumatology, Freiburg University Hospital, Freiburg, Germany.
4
Professor, Clinical Radiologist, Department of Radiology, RKK-Klinikum Freiburg, Freiburg, Germany.
5
Professor, Orthopaedic Surgeon, alphaclinic Zurich, International Centers for Sports Medicine and Joint Surgery, Zurich, Switzerland.

Abstract

Autologous chondrocyte implantation (ACI) is a first-line treatment option for large articular cartilage defects. Although well-established for cartilage defects in the knee, studies of the long-term outcomes of matrix-assisted ACI to treat cartilage defects in the ankle are rare. In the present report, we describe for the first time the long-term clinical and radiologic results 12 years after polymer-based matrix-assisted ACI treat a full-thickness talar cartilage defect in a 25-year-old male patient. The clinical outcome was assessed using the visual analog scale and Freiburg ankle score, magnetic resonance imaging evaluation using the Henderson-Kreuz scoring system and T2 mapping. Clinical assessment revealed improved visual analog scale and Freiburg ankle scores. The radiologic analysis and T2 relaxation time values indicated the formation of hyaline-like repair tissue. Polymer-based autologous chondrocytes has been shown to be a safe and clinically effective long-term treatment of articular cartilage defects in the talus.

KEYWORDS:

ankle; articular cartilage; autologous chondrocyte implantation; long-term follow-up; scaffold

PMID:
28633793
DOI:
10.1053/j.jfas.2017.03.001
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center