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J Gen Virol. 2017 Jun;98(6):1145-1158. doi: 10.1099/jgv.0.000780. Epub 2017 Jun 20.

Human picornaviruses associated with neurological diseases and their neutralization by antibodies.

Author information

1
1​Institute of Biotechnology and Department of Biosciences, University of Helsinki, Viikinkaari 1, 00790 Helsinki, Finland 2​Protobios LLC, Mäealuse 4, 12618 Tallinn, Estonia.
2
1​Institute of Biotechnology and Department of Biosciences, University of Helsinki, Viikinkaari 1, 00790 Helsinki, Finland.
3
2​Protobios LLC, Mäealuse 4, 12618 Tallinn, Estonia 3​Institute of Chemistry and Biotechnology, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn, Estonia.

Abstract

Picornaviruses are the most commonly encountered infectious agents in mankind. They typically cause mild infections of the gastrointestinal or respiratory tract, but sometimes also invade the central nervous system. There, they can cause severe diseases with long-term sequelae and even be lethal. The most infamous picornavirus is poliovirus, for which significant epidemics of poliomyelitis were reported from the end of the nineteenth century. A successful vaccination campaign has brought poliovirus close to eradication, but neurological diseases caused by other picornaviruses have increasingly been reported since the late 1990s. In this review we focus on enterovirus 71, coxsackievirus A16, enterovirus 68 and human parechovirus 3, which have recently drawn attention because of their links to severe neurological diseases. We discuss the clinical relevance of these viruses and the primary role of humoral immunity in controlling them, and summarize current knowledge on the neutralization of such viruses by antibodies.

PMID:
28631594
DOI:
10.1099/jgv.0.000780
[Indexed for MEDLINE]

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