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J Med Primatol. 2018 Feb;47(1):3-17. doi: 10.1111/jmp.12283. Epub 2017 Jun 16.

Diet-induced early-stage atherosclerosis in baboons: Lipoproteins, atherogenesis, and arterial compliance.

Author information

1
South Texas Diabetes and Obesity Institute, School of Medicine, The University of Texas Rio Grande Valley, Brownsville, TX, USA.
2
Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.
3
Department of Nutrition and UNC Nutrition Research Institute, University of North Carolina, Kannapolis, NC, USA.
4
Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.

Abstract

BACKGROUND:

The purpose of this study was to determine whether dietary manipulation can reliably induce early-stage atherosclerosis and clinically relevant changes in vascular function in an established, well-characterized non-human primate model.

METHODS:

We fed 112 baboons a high-cholesterol, high-fat challenge diet for two years. We assayed circulating biomarkers of cardiovascular disease (CVD) risk, at 0, 7, and 104 weeks into the challenge; assessed arterial compliance noninvasively at 104 weeks; and measured atherosclerotic lesions in three major arteries at necropsy.

RESULTS:

We observed evidence of atherosclerosis in all but one baboon fed the two-year challenge diet. CVD risk biomarkers, the prevalence, size, and complexity of arterial lesions, plus consequent arterial stiffness, were increased in comparison with dietary control animals.

CONCLUSIONS:

Feeding baboons a high-cholesterol, high-fat diet for two years reliably induces atherosclerosis, with risk factor profiles, arterial lesions, and changes in vascular function also seen in humans.

KEYWORDS:

cardiovascular disease; high-fat diet; non-human primate

PMID:
28620920
PMCID:
PMC5839476
[Available on 2019-02-01]
DOI:
10.1111/jmp.12283

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